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Services / Preformulation Studies

In pre-formulation studies, we characterize the drug candidate for its molecular and material properties such as crystallinity and solubility properties. We will screen variety of biocompatible co-solvents and buffers as well as evaluate role of cyclodextrins and micellar solubilization using surfactants. Furthermore, drug-excipient compatibility as well as use forced degradation studies are performed to examine if any added substances such as antioxidants, chelating agents, and other complexing agents are needed to achieve desired solubility and stability.

Relevant Instruments

DensitometerMETTLER TOLEDODensito 30PX
Differential Scanning CalorimeterPerkinElmerDSC4000
Freeze Drying MicroscopeLinkamOlympus BX51
HPLC-CAD SystemPeak Scientific Instruments Ltd.Corona Nitrogen 1010
HPLC-RIDSHIMADZURID-20A
HPLC-UV SystemSHIMADZULC-2010AHT
HPLC-UV SystemSHIMADZULC-2010AHT
Karl-Fischer CoulometerMetrohm831 KF Coulometer
OsmometerADVANCED INSTRUMENTS INC.Model 3320
Oxygen MeterPreSensMicrox 4
Particle Size Distribution AnalyzerShimadzuSALD-2300
Particle Size Measurement System HIAC9703+
PolarimeterAzzota CorporationAP-45
RheometerTA InstrumentsDiscovery HR-2
Texture AnalyzerStable Micro SystemsTA.XT plus Texture Analyzer
Type IV Dissolution ApparatusSOTAXCE7 smart
UV-Vis SpectrophotometerAzzota CorporationSM1000 UV-Vis Spectrophotometer
ViscometerRHEOSENSE, INC.uVISC
Zeta Potential MeterMicrotracZETA-check PMX 500

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